Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DROSHA (Q9NRR4) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed3
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria1


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5B16_A Ribonuclease 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 67.9 74.2 Yes Yes
2 empty 2.08 69.5 56 No No
3 empty 1.91 75.3 42.7 No No
4 empty 2.06 66.8 30.6 No No
5 empty 1.97 71 22 No No
6 empty 2.14 65.8 21.3 No No
7 empty 2.19 63.7 28.6 No No
8 empty 2.52 70.6 25.9 No No
9 empty 1.57 70.6 18.8 No No
10 empty 2.55 67.4 18.9 No No
2NA2_A Ribonuclease 3 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 64.1 22 No No
2 empty 2.49 68.1 12.9 No No
3 empty 2.05 69.9 12.8 No No
4 empty 1.55 59.9 21.1 No No
5 empty 1.85 46.8 12.9 No No
6 empty 2.16 55.8 10.3 No No
7 empty 1.75 62.8 11.2 No No
8 empty 2.73 62.3 7.1 No No
9 empty 1.79 72.2 6.7 No No
10 empty 2.22 57.9 8.1 No No
2KHX_A Ribonuclease 3 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 63.7 20.8 No No
2 empty 2.05 62.3 14.4 No No
3 empty 2.4 63.1 14.8 No No
4 empty 2.05 63.3 13.3 No No
5 empty 2.18 68.8 9.5 No No
6 empty 2.04 68.1 9.2 No No
7 empty 2.16 70.2 9.5 No No
8 empty 1.54 73.2 10 No No
9 empty 3.13 68.1 7.3 No No
10 empty 2.43 57.8 9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria0

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2KHX_A (3140900) Ribonuclease 3 dsRBD-like, dsRNA-binding domain-like, Double-stranded RNA-binding domain (dsRBD) No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


DROSHA is involved in 4 interactions in the network.


Druggability
Overall Druggability Percentile: 67.09
Druggability for Cancer Therapeutics: 58.46
Druggability for Other Therapeutics: 75.35
Cancer-Associated
Cancer-associated percentile : 67.97
Network Articulation Point
Is DROSHA critical for communication in the network?


Detailed Graph Legend:Help