Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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Gene Copy Number Variation
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Germline Genetics

STK36 (Q9NRP7) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein kinase domain (96%) (view alignment) TPK1 (P06244) - BAKER'S YEAST 1FOT_A 35.51 2.0E-42 2.8Å - 2001-06-13
Protein kinase domain (96%) (view alignment) MARK2 (Q7KZI7) - HUMAN 5KZ7_A 36.51 1.0E-39 3.2Å 6Z2 2017-05-31
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6HXF_D 35.98 6.0E-40 2.09Å R70 2018-10-31
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6GTT_A 35.98 1.0E-39 2.25Å B96 2018-06-27
Protein kinase domain (96%) (view alignment) MARK2 (Q7KZI7) - HUMAN 5KZ7_B 36.51 1.0E-39 3.2Å 6Z2 2017-05-31
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - 2R0I_B 36.51 1.0E-39 2.2Å - 2008-08-26
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 5OWR_A 35.98 6.0E-40 2.3Å 1N1 2017-09-13
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6HXF_B 35.98 6.0E-40 2.09Å R70 2018-10-31
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - NORWAY RAT 1Y8G_B 36.51 2.0E-39 2.5Å - 2006-02-14
Protein kinase domain (100%) (view alignment) SLK (Q9H2G2) - HUMAN 4USF_B 35.47 2.0E-41 1.75Å 6UI 2015-07-22
Protein kinase domain (100%) (view alignment) ULK3 (Q6PHR2) - HUMAN 6FDY_U 38.49 4.0E-42 1.7Å DB8 2018-08-01
Protein kinase domain (100%) (view alignment) SLK (Q9H2G2) - HUMAN 2J51_A 35.34 6.0E-42 2.1Å DKI 2006-10-03
Protein kinase domain (100%) (view alignment) MARK3 (P27448) - HUMAN 3FE3_A 35.41 4.0E-40 1.9Å - 2008-12-16
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4USE_B 35.98 6.0E-40 2.65Å R09 2015-07-22
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4AOT_B 35.98 6.0E-40 2.33Å GW8 2012-04-11
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - NORWAY RAT 1ZMV_A 36.1 2.0E-39 3.1Å - 2006-02-14
Protein kinase domain (100%) (view alignment) ULK3 (Q6PHR2) - HUMAN 6FDZ_U 38.49 4.0E-42 2.55Å C87 2018-08-01
Protein kinase domain (100%) (view alignment) STK3 (Q13188) - HUMAN 5DH3_B 36.05 3.0E-39 2.45Å 5BS 2016-08-31
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4USE_A 35.98 6.0E-40 2.65Å R09 2015-07-22
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 5AJQ_A 35.98 7.0E-40 2.2Å DB8 2015-03-11
Protein kinase domain (100%) (view alignment) AURKC (Q9UQB9) INCENP (Q9NQS7) HUMAN 6GR8_A 36.33 3.0E-43 1.75Å F8Z 2019-05-15
Protein kinase domain (96%) (view alignment) AKT2 (P31751) - HUMAN 1GZK_A 35.1 1.0E-42 2.3Å - 2003-05-22
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6HXF_A 35.98 6.0E-40 2.09Å R70 2018-10-31
Protein kinase domain (100%) (view alignment) MARK3 (P27448) - HUMAN 2QNJ_B 35.41 2.0E-40 2.69Å - 2007-09-04
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - NORWAY RAT 1ZMW_B 36.51 2.0E-39 2.8Å - 2006-02-14
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4EQU_A 35.98 6.0E-40 2Å G6I 2012-11-07
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 5AJQ_B 35.98 7.0E-40 2.2Å DB8 2015-03-11
Protein kinase domain (100%) (view alignment) SLK (Q9H2G2) - HUMAN 6HVD_A 35.47 2.0E-41 1.63Å GUQ 2018-10-17
Protein kinase domain (100%) (view alignment) SLK (Q9H2G2) - HUMAN 2UV2_A 35.34 6.0E-42 2.3Å GVD 2007-03-20
Protein kinase domain (100%) (view alignment) (A3FQ16) - 3DFA_A 35.11 4.0E-40 2.45Å - 2008-07-29
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - NORWAY RAT 1Y8G_A 36.51 2.0E-39 2.5Å - 2006-02-14
Protein kinase domain (100%) (view alignment) AURKC (Q9UQB9) INCENP (Q9NQS7) HUMAN 6GR9_A 36.33 3.0E-43 2.25Å VX6 2019-05-15
Protein kinase domain (96%) (view alignment) AKT2 (P31751) GSK3B (P49841) HUMAN 2X39_A 35.1 2.0E-42 1.93Å X39 2010-02-23
Protein kinase domain (100%) (view alignment) NEK1 (Q96PY6) - HUMAN 4APC_A 36.3 5.0E-42 2.1Å - 2012-04-25
Protein kinase domain (100%) (view alignment) CPK2 (O15865) - 4MVF_A 35.34 1.0E-42 2Å STU 2014-09-03
Protein kinase domain (100%) (view alignment) SLK (Q9H2G2) - HUMAN 2JFM_A 35.34 6.0E-42 2.85Å - 2007-02-27
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - NORWAY RAT 1ZMV_B 36.1 2.0E-39 3.1Å - 2006-02-14
Protein kinase domain (100%) (view alignment) NEK1 (Q96PY6) - HUMAN 4B9D_A 36.3 5.0E-42 1.9Å CK7 2012-09-19
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 2J7T_A 35.98 6.0E-40 2Å 274 2006-11-07
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - NORWAY RAT 1ZMU_B 36.51 1.0E-39 2.9Å - 2006-02-14
Protein kinase domain (96%) (view alignment) MARK2 (Q7KZI7) - HUMAN 5EAK_A 36.51 1.0E-39 2.8Å 24R 2016-02-17
Protein kinase domain (100%) (view alignment) NEK1 (Q96PY6) - HUMAN 4APC_B 36.3 5.0E-42 2.1Å - 2012-04-25
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4EQU_B 35.98 6.0E-40 2Å G6I 2012-11-07
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6I2Y_B 35.98 1.0E-39 2.56Å 88Z 2018-12-12
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4AOT_A 35.98 6.0E-40 2.33Å GW8 2012-04-11
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4USD_B 35.98 6.0E-40 3.05Å R09 2015-07-22
Protein kinase domain (96%) (view alignment) AKT2 (P31751) GSK3B (P49841) HUMAN 2JDR_A 35.1 2.0E-42 2.3Å L20 2007-02-13
Protein kinase domain (100%) (view alignment) (A3FQ16) - 2WEI_A 35.11 4.0E-40 1.65Å VGG 2009-04-28
Protein kinase domain (100%) (view alignment) NEK1 (Q96PY6) - HUMAN 4B9D_B 36.3 5.0E-42 1.9Å CK7 2012-09-19
Protein kinase domain (100%) (view alignment) MARK3 (P27448) - HUMAN 2QNJ_A 35.41 2.0E-40 2.69Å - 2007-09-04
Protein kinase domain (100%) (view alignment) MARK4 (Q96L34) - HUMAN 5ES1_A 35.18 2.0E-41 2.8Å 5RC 2015-12-02
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6EIM_B 35.61 1.0E-39 1.43Å B6E 2017-11-01
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4USD_A 35.98 6.0E-40 3.05Å R09 2015-07-22
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - NORWAY RAT 1ZMW_A 36.51 2.0E-39 2.8Å - 2006-02-14
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6HXF_C 35.98 6.0E-40 2.09Å R70 2018-10-31
Protein kinase domain (96%) (view alignment) MARK2 (Q7KZI7) - HUMAN 5KZ8_B 36.51 1.0E-39 3.2Å 6Z5 2017-05-31
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - NORWAY RAT 1ZMU_A 36.51 1.0E-39 2.9Å - 2006-02-14
Protein kinase domain (96%) (view alignment) Mark2 (O08679) - 2R0I_A 36.51 1.0E-39 2.2Å - 2008-08-26
Protein kinase domain (96%) (view alignment) AKT2 (P31751) - HUMAN 1GZO_A 35.1 1.0E-42 2.75Å - 2003-05-22
Protein kinase domain (100%) (view alignment) STK4 (Q13043) - HUMAN 3COM_B 35.27 7.0E-40 2.2Å - 2008-04-15
Protein kinase domain (96%) (view alignment) AKT2 (P31751) GSK3B (P49841) HUMAN 2JDO_A 35.1 2.0E-42 1.8Å I5S 2007-02-13
Protein kinase domain (100%) (view alignment) SLK (Q9H2G2) - HUMAN 4USF_A 35.47 2.0E-41 1.75Å 6UI 2015-07-22
Protein kinase domain (100%) (view alignment) SLK (Q9H2G2) - HUMAN 2JFL_A 35.34 6.0E-42 2.2Å DKI 2007-02-27
Protein kinase domain (96%) (view alignment) AKT2 (P31751) GSK3B (P49841) HUMAN 1O6L_A 35.1 2.0E-42 1.6Å ANP 2002-11-19
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6EIM_A 35.61 1.0E-39 1.43Å B6E 2017-11-01
Protein kinase domain (100%) (view alignment) MARK3 (P27448) - HUMAN 3FE3_B 35.41 4.0E-40 1.9Å - 2008-12-16
Protein kinase domain (96%) (view alignment) MARK2 (Q7KZI7) - HUMAN 5KZ8_A 36.51 1.0E-39 3.2Å 6Z5 2017-05-31
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 4BC6_A 35.98 5.0E-40 2.2Å XZN 2012-10-10
Protein kinase domain (96%) (view alignment) AKT2 (P31751) GSK3B (P49841) HUMAN 2XH5_A 35.1 2.0E-42 2.72Å X37 2010-06-16
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 6I2Y_A 35.98 1.0E-39 2.56Å 88Z 2018-12-12
Protein kinase domain (100%) (view alignment) STK4 (Q13043) - HUMAN 3COM_A 35.27 7.0E-40 2.2Å - 2008-04-15
Protein kinase domain (96%) (view alignment) MARK2 (Q7KZI7) - HUMAN 5EAK_B 36.51 1.0E-39 2.8Å 24R 2016-02-17
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 5OWQ_B 35.98 6.0E-40 2.7Å 38O 2017-09-13
Protein kinase domain (96%) (view alignment) AKT2 (P31751) GSK3B (P49841) HUMAN 2UW9_A 35.1 2.0E-42 2.1Å GVP 2007-05-08
Protein kinase domain (100%) (view alignment) STK10 (O94804) - HUMAN 5OWQ_A 35.98 6.0E-40 2.7Å 38O 2017-09-13