STK36 (Q9NRP7) - Overview - Molecular Target Synopsis
STK36, Serine/threonine-protein kinase 36
Enzyme Classification 18.104.22.168
Also Known as STK36_HUMAN, STK36, KIAA1278
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia. Interacts with GLI1, GLI2 and GLI3 (PubMed:10806483). Interacts with SPAG16 and KIF27.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|1315||ENSG00000163482||ENST00000295709, ENST00000440309||ENSP00000295709, ENSP00000394095||Q9NRP7-1|
UniProt: STK36 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: STK36 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular region, nucleus.