Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AASDHPPT (Q9NRN7) - Overview - Molecular Target Synopsis

Protein


AASDHPPT, L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Enzyme Classification 2.7.8.7
UniProt Q9NRN7

Also Known as ADPPT_HUMAN, AASDHPPT

Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. Monomer. Interacts with FASN.

2CG5
STRUCTURE OF AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE- PHOSPHOPANTETHEINYL TRANSFERASE IN COMPLEX WITH CYTOSOLIC ACYL CARRIER PROTEIN AND COENZYME A
RCSB/PDB
Inspect Structure
See all 3D Structures for AASDHPPT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AASDHPPT is active in the following subcellular-locations: cytoplasm.
GO terms: AASDHPPT is active in the following subcellular-locations: cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AASDHPPT has gain in 4 cell-lines, loss in 7 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, K_562, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BJAB, KARPAS-422, TK

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


For AASDHPPT there are:
3 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AASDHPPT has been screened with 3 compounds (3 bioactivities). (see details)