Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

OLFML3 (Q9NRN5) - Overview - Molecular Target Synopsis

Protein


OLFML3, Olfactomedin-like protein 3
UniProt Q9NRN5

Also Known as OLFL3_HUMAN, OLFML3

Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: OLFML3 is active in the following subcellular-locations: secreted.
GO terms: OLFML3 is active in the following subcellular-locations: extracellular vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project OLFML3 has gain in 8 cell-lines, loss in 3 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, SF_539, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-415, A-673, MHH-ES-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, BJ

(see details)