Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A9 (Q9NRM0) - Overview - Molecular Target Synopsis

Protein


SLC2A9, Solute carrier family 2, facilitated glucose transporter member 9
UniProt Q9NRM0

Also Known as GTR9_HUMAN, SLC2A9, GLUT9

Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC2A9 is active in the following subcellular-locations: apical cell membrane, basolateral cell membrane.
GO terms: SLC2A9 is active in the following subcellular-locations: apical plasma membrane, basolateral plasma membrane, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A9 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, SK_MEL_5, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: THP-1, SKM-1, SCC-15

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, SK-N-SH

(see details)

3D Structures


At greater than 35% identity similarity to SLC2A9 there are:
10 structures (13 chains) solved
8 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A9 is solved in complex with the approved drug(s):

BGC/DEXTROSE (4ZW9_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC2A9 has been screened with 2 compounds (2 bioactivities). (see details)