Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCB10 (Q9NRK6) - Overview - Molecular Target Synopsis

Protein


ABCB10, ATP-binding cassette sub-family B member 10, mitochondrial
UniProt Q9NRK6

Also Known as ABCBA_HUMAN, ABCB10

May mediate critical mitochondrial transport functions related to heme biosynthesis. Homodimer or homooligomer.

3ZDQ
STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (NUCLEOTIDE-FREE FORM)
RCSB/PDB
Inspect Structure
See all 3D Structures for ABCB10

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
738ENSG00000135776ENST00000344517ENSP00000355637Q9NRK6-1

Sub-cellular localization


UniProt: ABCB10 is active in the following subcellular-locations: mitochondrion inner membrane.
GO terms: ABCB10 is active in the following subcellular-locations: integral component of membrane, integral component of mitochondrial membrane, mitochondrial inner membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCB10 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HL_60, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-AML2, HL-60, KU812

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, HeLa-S3

(see details)

3D Structures


For ABCB10 there are:
4 structures (4 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCB10 has been screened with compounds ( bioactivities). (see details)