Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SNRK (Q9NRH2) - Overview - Molecular Target Synopsis

Protein


SNRK, SNF-related serine/threonine-protein kinase
Enzyme Classification 2.7.11.1
UniProt Q9NRH2

Also Known as SNRK_HUMAN, SNRK, KIAA0096, SNFRK

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.

5YKS
CRYSTAL STRUCTURE OF SUCROSE NONFERMENTING-RELATED KINASE (SNRK)
RCSB/PDB
Inspect Structure
See all 3D Structures for SNRK

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SNRK is active in the following subcellular-locations: nucleus.
GO terms: SNRK is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SNRK has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, PC_3, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TYK-nu, TYK-nu.CP-r, HNT-34

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, SK-N-SH, NHLF

(see details)

RNA Interference


SNRK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVISE, OVAS. (see details)

3D Structures


For SNRK there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SNRK has been screened with 87 compounds (87 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)