Molecular Target Synopsis
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SDR39U1 (Q9NRG7) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4B4O_F Epimerase family protein SDR39U1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 77.4 42.2 Yes Yes
2 empty 2.1 63.8 30.3 No No
3 empty 2.04 66.4 30.3 No No
4 empty 2.35 65.1 24.5 No No
5 empty 2.35 63.1 20.9 No No
6 empty 2.1 60 16.1 No No
7 empty 2.61 63.4 16.8 No No
8 empty 2.03 72.6 8.7 No No
9 empty 2.39 78.8 9.7 No No
10 empty 1.48 65.1 8.9 No No
4B4O_G Epimerase family protein SDR39U1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 83.4 33.2 Yes Yes
2 empty 1.99 65.6 26.9 No No
3 bound 2.03 59.3 16 No No
4 empty 2.18 62.7 17.2 No No
5 empty 2.02 65.9 14.6 No No
6 empty 2.06 53.7 12.6 No No
7 empty 2.49 55.4 13.7 No No
8 empty 1.8 61.5 12.5 No No
9 bound 1.68 67.8 10.7 No No
10 bound 1.84 97.6 0 Yes No
4B4O_C Epimerase family protein SDR39U1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 78 44.1 Yes Yes
2 empty 2.09 68.3 30.4 No No
3 empty 2.33 65.4 30.7 No No
4 empty 2.47 64.6 17.6 No No
5 empty 2.57 64.9 17.2 No No
6 empty 2.07 69.8 11.8 No No
7 empty 2.35 64 13.8 No No
8 empty 2.11 66 11.5 No No
9 empty 2.24 63.5 11.6 No No
10 empty 2.27 78.8 8.5 No No
4B4O_E Epimerase family protein SDR39U1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 82.3 37.7 Yes Yes
2 empty 2.05 65.3 26.1 No No
3 bound 2.11 58.6 18.1 No No
4 empty 2.15 61.2 15.9 No No
5 empty 2.31 55.8 19.5 No No
6 empty 2.01 63.6 14 No No
7 bound 2.07 69.2 9.2 No No
8 bound 1.62 98.8 0 Yes No
9 empty 1.91 61.8 9.2 No No
10 empty 1.81 67.1 7.6 No No
4B4O_D Epimerase family protein SDR39U1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 78 45 Yes Yes
2 empty 1.99 64.3 29.9 No No
3 empty 2.26 68 30.8 No No
4 empty 2.41 64 20.4 No No
5 empty 2.2 58.4 15.3 No No
6 empty 2.69 63.5 18 No No
7 empty 1.89 62.3 10.3 No No
8 empty 1.94 72.7 8.9 No No
9 empty 2.39 75.8 7.1 No No
10 empty 2.08 67.8 8.3 No No
4B4O_A Epimerase family protein SDR39U1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 78 44 Yes Yes
2 empty 2.24 64.5 32.4 No No
3 empty 2 66.1 25 No No
4 empty 2.17 61.1 15.8 No No
5 empty 2.24 67.1 13.3 No No
6 empty 2.52 63.4 17.3 No No
7 empty 2.39 64.9 13.6 No No
8 empty 1.83 63.5 13.3 No No
9 empty 1.98 68 9.4 No No
10 empty 1.94 71.5 11.1 No No
4B4O_B Epimerase family protein SDR39U1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 77.4 38.3 Yes Yes
2 empty 1.95 66.7 30.1 No No
3 empty 2.11 66.3 29.9 No No
4 empty 2.39 62.3 20.7 No No
5 empty 2.64 64.5 18.7 No No
6 empty 1.94 60.1 18 No No
7 empty 2.44 71.9 10.8 No No
8 empty 2.57 54 11.7 No No
9 empty 2.16 71.7 9.5 No No
10 empty 2.26 63.5 12.5 No No
4B4O_H Epimerase family protein SDR39U1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 77.5 39.9 Yes Yes
2 empty 1.95 67.5 30.4 No No
3 empty 1.68 67 27.6 No No
4 empty 2.1 64.2 13 No No
5 empty 1.74 66.3 14.6 No No
6 empty 2.56 65.9 15.9 No No
7 empty 2.05 72.4 10.2 No No
8 empty 1.73 71.6 10.7 No No
9 empty 2.21 57.3 11.3 No No
10 empty 2.3 61 7.8 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


SDR39U1 is involved in 1 interactions in the network.


Druggability
Overall Druggability Percentile: 17.91
Druggability for Cancer Therapeutics: 4.05
Druggability for Other Therapeutics: 17.39
Cancer-Associated
Cancer-associated percentile : 17.23
Network Articulation Point
Is SDR39U1 critical for communication in the network?


Detailed Graph Legend:Help