SLC17A5 (Q9NRA2) - Overview - Molecular Target Synopsis
Also Known as S17A5_HUMAN, SLC17A5
Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: SLC17A5 is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, lysosome membrane, secretory vesicle, synaptic vesicle membrane.
GO terms: SLC17A5 is active in the following subcellular-locations: cell junction, cytosol, integral component of membrane, integral component of plasma membrane, lysosomal membrane, lysosome, membrane, plasma membrane, synaptic vesicle membrane.