Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC17A5 (Q9NRA2) - Overview - Molecular Target Synopsis

Protein


SLC17A5, Sialin
UniProt Q9NRA2

Also Known as S17A5_HUMAN, SLC17A5

Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
495ENSG00000119899ENST00000355773ENSP00000348019Q9NRA2-1
277Q9NRA2-2
181ENSG00000119899ENST00000393019ENSP00000376742

Sub-cellular localization


UniProt: SLC17A5 is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, lysosome membrane, secretory vesicle, synaptic vesicle membrane.
GO terms: SLC17A5 is active in the following subcellular-locations: cell junction, cytosol, integral component of membrane, integral component of plasma membrane, lysosomal membrane, lysosome, membrane, plasma membrane, synaptic vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC17A5 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, HCC_2998, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, RERF-LC-KJ, Hs 38.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, IMR-90

(see details)


Screening and Chemistry


SLC17A5 has been screened with compounds ( bioactivities). (see details)