Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SAR1A (Q9NR31) - Overview - Molecular Target Synopsis

Protein


SAR1A, GTP-binding protein SAR1a
UniProt Q9NR31

Also Known as SAR1A_HUMAN, SAR1A, SAR1, SARA, SARA1

Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). Interacts with B3GAT1.

2GAO
CRYSTAL STRUCTURE OF HUMAN SAR1A IN COMPLEX WITH GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for SAR1A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SAR1A is active in the following subcellular-locations: endoplasmic reticulum, golgi apparatus.
GO terms: SAR1A is active in the following subcellular-locations: COPII vesicle coat, endoplasmic reticulum, endoplasmic reticulum exit site, Golgi membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SAR1A has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, RXF_393, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, PC-3, OVCAR-8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


For SAR1A there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SAR1A has been screened with compounds ( bioactivities). (see details)