Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DYRK4 (Q9NR20) - Overview - Molecular Target Synopsis

Protein


DYRK4, Dual specificity tyrosine-phosphorylation-regulated kinase 4
Enzyme Classification 2.7.12.1
UniProt Q9NR20

Also Known as DYRK4_HUMAN, DYRK4

Possible non-essential role in spermiogenesis.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DYRK4 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: DYRK4 is active in the following subcellular-locations: cytoplasm, intracellular membrane-bounded organelle, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DYRK4 has gain in 7 cell-lines, loss in 3 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, CCRF_CEM, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G111, DMS 53, NCI-H716

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, SK-N-SH, HMEC

(see details)

RNA Interference


DYRK4 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: T47D, MCF12A. (see details)

3D Structures


At greater than 50% identity similarity to DYRK4 there are:
7 structures (10 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DYRK4 has been screened with 34 compounds (37 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)