Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSS2 (Q9NR19) - Overview - Molecular Target Synopsis

Protein


ACSS2, Acetyl-coenzyme A synthetase, cytoplasmic
Enzyme Classification 6.2.1.1
UniProt Q9NR19

Also Known as ACSA_HUMAN, ACSS2, ACAS2

Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSS2 is active in the following subcellular-locations: cytoplasm.
GO terms: ACSS2 is active in the following subcellular-locations: cytoplasm, cytosol, intracellular membrane-bounded organelle, mitochondrial matrix, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSS2 has gain in 12 cell-lines, loss in 1 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, UACC_62, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-16, HT-55, RCM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, HMEC

(see details)

3D Structures


At greater than 50% identity similarity to ACSS2 there are:
10 structures (19 chains) solved
9 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ACSS2 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2P2F_A, 2P2F_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACSS2 has been screened with compounds ( bioactivities). (see details)