Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC52A3 (Q9NQ40) - Overview - Molecular Target Synopsis

Protein


SLC52A3, Solute carrier family 52, riboflavin transporter, member 3
UniProt Q9NQ40

Also Known as S52A3_HUMAN, SLC52A3, C20orf54, RFT2, RFVT3

Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption (PubMed:20463145, PubMed:24264046, PubMed:22273710, PubMed:27702554). Riboflavin transport is Na(+)-independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions (PubMed:24264046).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
469ENSG00000101276ENST00000217254ENSP00000217254Q9NQ40-1
415ENSG00000101276ENST00000381944ENSP00000371370Q9NQ40-2

Sub-cellular localization


UniProt: SLC52A3 is active in the following subcellular-locations: apical cell membrane, cell membrane, cytoplasm, nucleus membrane.
GO terms: SLC52A3 is active in the following subcellular-locations: apical plasma membrane, cytoplasm, integral component of plasma membrane, nuclear membrane, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC52A3 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LS1034, MDA-MB-175-VII, OCUM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)