Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LUC7L (Q9NQ29) - Overview - Molecular Target Synopsis

Protein


LUC7L, Putative RNA-binding protein Luc7-like 1
UniProt Q9NQ29

Also Known as LUC7L_HUMAN, LUC7L, LUC7L1

May bind to RNA via its Arg/Ser-rich domain.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: LUC7L is active in the following subcellular-locations: U1 snRNP, U2-type prespliceosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LUC7L has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_ADR_RES, SF_295, OVCAR_8

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H187, KELLY, SK-N-DZ

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, MCF-7

(see details)

3D Structures


At greater than 50% identity similarity to LUC7L there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis