Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACP6 (Q9NPH0) - Overview - Molecular Target Synopsis

Protein


ACP6, Lysophosphatidic acid phosphatase type 6
Enzyme Classification 3.1.3.2
UniProt Q9NPH0

Also Known as PPA6_HUMAN, ACP6, ACPL1, LPAP

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. Monomer.

4JOB
CRYSTAL STRUCTURE OF HUMAN LYSOPHOSPHATIDIC ACID PHOSPHATASE TYPE 6 COMPLEXED WITH L-(+)-TARTRATE
RCSB/PDB
Inspect Structure
See all 3D Structures for ACP6

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACP6 is active in the following subcellular-locations: mitochondrion.
GO terms: ACP6 is active in the following subcellular-locations: cytoplasm, mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACP6 has gain in 14 cell-lines, loss in 0 cell-lines and no signal in 991 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, HOP_62, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 695T, HCC2302, HCC2270

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, MCF-7, NHLF

(see details)

3D Structures


For ACP6 there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis