Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IL23A (Q9NPF7) - Overview - Molecular Target Synopsis

Protein


IL23A, Interleukin-23 subunit alpha
UniProt Q9NPF7

Also Known as IL23A_HUMAN, IL23A, SGRF

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

5NJD
STRUCTURE OF INTERLEUKIN 23 IN COMPLEX WITH BRIAKINUMAB FAB
RCSB/PDB
Inspect Structure
See all 3D Structures for IL23A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
189ENSG00000110944ENST00000228534ENSP00000228534Q9NPF7-1

Sub-cellular localization


UniProt: IL23A is active in the following subcellular-locations: secreted.
GO terms: IL23A is active in the following subcellular-locations: endoplasmic reticulum lumen, extracellular region, interleukin-23 complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IL23A has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, K_562, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H820, U266B1, HCC1482

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, NHLF, HSMM

(see details)

3D Structures


For IL23A there are:
10 structures (18 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis