Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLCO1B3 (Q9NPD5) - Overview - Molecular Target Synopsis

Protein


SLCO1B3, Solute carrier organic anion transporter family member 1B3
UniProt Q9NPD5

Also Known as SO1B3_HUMAN, SLCO1B3, LST2, OATP1B3, OATP8, SLC21A8

Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLCO1B3 is active in the following subcellular-locations: basolateral cell membrane.
GO terms: SLCO1B3 is active in the following subcellular-locations: basolateral plasma membrane, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLCO1B3 has gain in 12 cell-lines, loss in 5 cell-lines and no signal in 988 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, OVCAR_5, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, T84, HT-115

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLCO1B3 has been screened with 2085 compounds (2471 bioactivities), 12 compounds have bioactivities that show binding affinity of <= 500nM (14 bioactivities). (see details)