Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MYOZ1 (Q9NP98) - Overview - Molecular Target Synopsis

Protein


MYOZ1, Myozenin-1
UniProt Q9NP98

Also Known as MYOZ1_HUMAN, MYOZ1, MYOZ

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
299ENSG00000177791ENST00000359322ENSP00000352272Q9NP98-1

Sub-cellular localization


UniProt: MYOZ1 is active in the following subcellular-locations: cell projection, nucleus, pseudopodium.
GO terms: MYOZ1 is active in the following subcellular-locations: actin cytoskeleton, nucleus, pseudopodium, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MYOZ1 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_92, SK_OV_3, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, LN-18, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, SK-N-SH, NHLF

(see details)