Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MRPS30 (Q9NP92) - Overview - Molecular Target Synopsis

Protein


MRPS30, 39S ribosomal protein S30, mitochondrial
UniProt Q9NP92

Also Known as RT30_HUMAN, MRPS30, PDCD9

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL65 forms a heterodimer with mL37.

5OOL
STRUCTURE OF A NATIVE ASSEMBLY INTERMEDIATE OF THE HUMAN MITOCHONDRIAL RIBOSOME WITH UNFOLDED INTERFACIAL RRNA
RCSB/PDB
Inspect Structure
See all 3D Structures for MRPS30

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
439ENSG00000112996ENST00000507110ENSP00000424328Q9NP92-1

Sub-cellular localization


UniProt: MRPS30 is active in the following subcellular-locations: mitochondrion.
GO terms: MRPS30 is active in the following subcellular-locations: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MRPS30 has gain in 39 cell-lines, loss in 0 cell-lines and no signal in 966 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, K_562, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, KYSE-70, MFM-223

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, HSMM, A549

(see details)

3D Structures


For MRPS30 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis