Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB9B (Q9NP90) - Overview - Molecular Target Synopsis

Protein


RAB9B, Ras-related protein Rab-9B
UniProt Q9NP90

Also Known as RAB9B_HUMAN, RAB9B, RAB9L

Involved in the transport of proteins between the endosomes and the trans Golgi network. Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). The GTP-bound form but not the GDP-bound form interacts with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159).

2OCB
CRYSTAL STRUCTURE OF HUMAN RAB9B IN COMPLEX WITH A GTP ANALOGUE
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB9B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
212ENSG00000123570ENST00000243298ENSP00000243298
201Q9NP90-1

Sub-cellular localization


UniProt: RAB9B is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, phagosome, phagosome membrane.
GO terms: RAB9B is active in the following subcellular-locations: cytosol, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB9B has gain in 2 cell-lines, loss in 31 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, SNB_75, CAKI_1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1155, HCC12, NCI-H1092

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RAB9B there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB9B has been screened with compounds ( bioactivities). (see details)