Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCB9 (Q9NP78) - Overview - Molecular Target Synopsis

Protein


ABCB9, ATP-binding cassette sub-family B member 9
UniProt Q9NP78

Also Known as ABCB9_HUMAN, ABCB9, KIAA1520

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Homodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCB9 is active in the following subcellular-locations: lysosome membrane.
GO terms: ABCB9 is active in the following subcellular-locations: integral component of endoplasmic reticulum membrane, integral component of membrane, intracellular membrane-bounded organelle, lysosomal membrane, lysosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCB9 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, U251, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MOLP-8, NCI-H929, SUM 52PE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ABCB9 there are:
5 structures (9 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCB9 has been screened with 1 compounds (2 bioactivities). (see details)