Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ABCB9 (Q9NP78) - Overview - Molecular Target Synopsis


ABCB9, ATP-binding cassette sub-family B member 9
UniProt Q9NP78

Also Known as ABCB9_HUMAN, ABCB9, KIAA1520

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Homodimer.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ABCB9 is active in the following subcellular-locations: lysosome membrane.
GO terms: ABCB9 is active in the following subcellular-locations: integral component of endoplasmic reticulum membrane, integral component of membrane, intracellular membrane-bounded organelle, lysosomal membrane, lysosome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ABCB9 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HCT_116, U251, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MOLP-8, NCI-H929, SUM 52PE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to ABCB9 there are:
5 structures (9 chains) solved
5 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ABCB9 has been screened with 1 compounds (2 bioactivities). (see details)