Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB18 (Q9NP72) - Overview - Molecular Target Synopsis

Protein


RAB18, Ras-related protein Rab-18
UniProt Q9NP72

Also Known as RAB18_HUMAN, RAB18

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.

1X3S
CRYSTAL STRUCTURE OF HUMAN RAB18 IN COMPLEX WITH GPPNHP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB18

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB18 is active in the following subcellular-locations: cell membrane.
GO terms: RAB18 is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, Golgi apparatus, intracellular, plasma membrane, secretory granule membrane, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB18 has gain in 4 cell-lines, loss in 7 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, OVCAR_4, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-70, MFM-223, HCC38

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, NHEK, HSMM

(see details)

3D Structures


For RAB18 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB18 has been screened with compounds ( bioactivities). (see details)