Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC40A1 (Q9NP59) - Overview - Molecular Target Synopsis

Protein


SLC40A1, Solute carrier family 40 member 1
UniProt Q9NP59

Also Known as S40A1_HUMAN, SLC40A1, FPN1, IREG1, SLC11A3

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Identified in a complex with STOM.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC40A1 is active in the following subcellular-locations: cell membrane.
GO terms: SLC40A1 is active in the following subcellular-locations: basolateral plasma membrane, cytoplasm, cytosol, integral component of membrane, integral component of plasma membrane, intracellular, nucleoplasm, plasma membrane, synaptic vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC40A1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, CCRF_CEM, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M2, huH-1, T-47D

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, CD34-positive mobilized cell, HUVEC

(see details)