Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCB6 (Q9NP58) - Overview - Molecular Target Synopsis

Protein


ABCB6, ATP-binding cassette sub-family B member 6, mitochondrial
UniProt Q9NP58

Also Known as ABCB6_HUMAN, ABCB6, MTABC3, PRP, UMAT

Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. Homodimer.

3NH6
NUCLEOTIDE BINDING DOMAIN OF HUMAN ABCB6 (APO STRUCTURE)
RCSB/PDB
Inspect Structure
See all 3D Structures for ABCB6

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCB6 is active in the following subcellular-locations: cell membrane, endoplasmic reticulum membrane, endosome membrane, golgi apparatus membrane, mitochondrion outer membrane.
GO terms: ABCB6 is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular exosome, Golgi apparatus, Golgi membrane, integral component of mitochondrial outer membrane, mitochondrial envelope, mitochondrial outer membrane, mitochondrion, nucleoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCB6 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, SK_MEL_28, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UMC-11, BEN, MHH-ES-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


For ABCB6 there are:
4 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCB6 has been screened with compounds ( bioactivities). (see details)