Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Adar (Q9NII1) - Overview - Molecular Target Synopsis

Protein


Adar, Double-stranded RNA-specific editase Adar
Enzyme Classification 3.5.-.-
UniProt Q9NII1

Also Known as ADAR_DROME, Adar, hypnos-2

Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.

2LJH
NMR STRUCTURE OF DOUBLE-STRANDED RNA-SPECIFIC EDITASE ADAR
RCSB/PDB
Inspect Structure
See all 3D Structures for Adar

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
676Q9NII1-1
671Q9NII1-4
669Q9NII1-7
648Q9NII1-5
639Q9NII1-2
628Q9NII1-3
611Q9NII1-6

Sub-cellular localization


GO terms: Adar is active in the following subcellular-locations: cytoplasm, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Adar has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Adar there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis