Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

fabF (Q9KQH9) - Overview - Molecular Target Synopsis

Protein


fabF, 3-oxoacyl-[acyl-carrier-protein] synthase 2
Enzyme Classification 2.3.1.179
UniProt Q9KQH9

Also Known as FABF_VIBCH, fabF

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis. Homodimer.

4JRH
CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE II (FABF) FROM VIBRIO CHOLERAE (SPACE GROUP P43) AT 2.2 ANGSTROM
RCSB/PDB
Inspect Structure
See all 3D Structures for fabF

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
414Q9KQH9-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project fabF has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fabF there are:
2 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


fabF has been screened with compounds ( bioactivities). (see details)