Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

kdsA (Q9JZ55) - Overview - Molecular Target Synopsis

Protein


kdsA, 2-dehydro-3-deoxyphosphooctonate aldolase
Enzyme Classification 2.5.1.55
UniProt Q9JZ55

Also Known as KDSA_NEIMB, kdsA


4JTE
CRYSTAL STRUCTURE OF F114A MUTANT OF 3-DEOXY-D-MANNO-OCTULOSONATE 8- PHOSPHATE SYNTHASE (KDO8PS) FROM NEISSERIA MENINGITIDIS
RCSB/PDB
Inspect Structure
See all 3D Structures for kdsA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
280Q9JZ55-1

Sub-cellular localization


UniProt: kdsA is active in the following subcellular-locations: cytoplasm.
GO terms: kdsA is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project kdsA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For kdsA there are:
19 structures (76 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


kdsA has been screened with 6 compounds (6 bioactivities). (see details)