Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HRH3 (Q9JI35) - Overview - Molecular Target Synopsis

Protein


HRH3, Histamine H3 receptor
UniProt Q9JI35

Also Known as HRH3_CAVPO, HRH3

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
445Q9JI35-1
415Q9JI35-2

Sub-cellular localization


UniProt: HRH3 is active in the following subcellular-locations: cell membrane.
GO terms: HRH3 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HRH3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


HRH3 has been screened with 672 compounds (999 bioactivities), 483 compounds have bioactivities that show binding affinity of <= 500nM (639 bioactivities). (see details)