Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

G (Q9IH62) - Overview - Molecular Target Synopsis

Protein


G, Glycoprotein G
UniProt Q9IH62

Also Known as GLYCP_NIPAV, G

Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis. Interacts with host EFNB2 and host EFNB3.

2VWD
NIPAH VIRUS ATTACHMENT GLYCOPROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for G

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
602Q9IH62-1

Sub-cellular localization


UniProt: G is active in the following subcellular-locations: host cell membrane, virion membrane.
GO terms: G is active in the following subcellular-locations: host cell plasma membrane, integral component of membrane, viral envelope, virion membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project G has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For G there are:
4 structures (6 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

G is solved in complex with the approved drug(s):

BGC/DEXTROSE (3D12_A, 3D12_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


G has been screened with 19 compounds (19 bioactivities). (see details)