Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

hfq (Q9HUM0) - Overview - Molecular Target Synopsis

Protein


hfq, RNA-binding protein Hfq
UniProt Q9HUM0

Also Known as HFQ_PSEAE, hfq

RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Homohexamer.

6O1K
ARCHITECTURAL PRINCIPLES FOR HFQ/CRC-MEDIATED REGULATION OF GENE EXPRESSION. HFQ-CRC-AMIE 2:2:2 COMPLEX (CORE COMPLEX)
RCSB/PDB
Inspect Structure
See all 3D Structures for hfq

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: hfq is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project hfq has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For hfq there are:
14 structures (109 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis