Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MYO10 (Q9HD67) - Overview - Molecular Target Synopsis

Protein


MYO10, Unconventional myosin-X
UniProt Q9HD67

Also Known as MYO10_HUMAN, MYO10, KIAA0799

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts., Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion. Monomer, when in an inactive confomation in the cytosol. Homodimer in its active, membrane-bound conformation; antiparallel coiled coil-mediated dimer formation. Interacts strongly with CALM3 and weakly with CALM, the CALM3 interaction is essential for function in filopodial extension and motility. Interacts with ECPAS. Interacts with NEO1. Interacts with ITGB1 and ITGB3. Interacts with VASP (By similarity). Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding. Interacts with tubulin; ITGB5 or DCC binding inhibits tubulin binding.

5I0I
CRYSTAL STRUCTURE OF MYOSIN X MOTOR DOMAIN WITH 2IQ MOTIFS IN PRE- POWERSTROKE STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for MYO10

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MYO10 is active in the following subcellular-locations: cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, filopodium membrane, filopodium tip, lamellipodium, ruffle.
GO terms: MYO10 is active in the following subcellular-locations: cell cortex, cytosol, filopodium membrane, filopodium tip, lamellipodium, myosin complex, neuron projection, neuronal cell body, nucleolus, plasma membrane, ruffle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MYO10 has gain in 35 cell-lines, loss in 1 cell-lines and no signal in 969 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, CAKI_1, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, NIH:OVCAR-3, HCC2157

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: IMR-90, A549, NHLF

(see details)

3D Structures


For MYO10 there are:
7 structures (11 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MYO10 has been screened with compounds ( bioactivities). (see details)