Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RANGRF (Q9HD47) - Overview - Molecular Target Synopsis

Protein


RANGRF, Ran guanine nucleotide release factor
UniProt Q9HD47

Also Known as MOG1_HUMAN, RANGRF, MOG1, RANGNRF

May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375). Monomer. Interacts with RAN, both RAN-GTP and RAN-GDP (PubMed:11290418, PubMed:29040603). Competes with RCC1 for a common binding site on RAN and thereby inhibits RCC1-mediated nucleotide exchange (PubMed:29040603). Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A (PubMed:18184654).

5YFG
SOLUTION STRUCTURE OF HUMAN MOG1
RCSB/PDB
Inspect Structure
See all 3D Structures for RANGRF

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RANGRF is active in the following subcellular-locations: cell membrane, cytoplasm, nucleus, perinuclear region.
GO terms: RANGRF is active in the following subcellular-locations: caveola, cytoplasm, cytosol, intercalated disc, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, rough endoplasmic reticulum.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RANGRF has gain in 1 cell-lines, loss in 8 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, U251, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SF268, KYSE-70, MHH-PREB-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HeLa-S3

(see details)

3D Structures


For RANGRF there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis