Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TRPC7 (Q9HCX4) - Overview - Molecular Target Synopsis


TRPC7, Short transient receptor potential channel 7
UniProt Q9HCX4

Also Known as TRPC7_HUMAN, TRPC7, TRP7

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: TRPC7 is active in the following subcellular-locations: cell membrane, nucleus envelope.
GO terms: TRPC7 is active in the following subcellular-locations: cation channel complex, cis-Golgi network, integral component of plasma membrane, nuclear envelope, perinuclear region of cytoplasm, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TRPC7 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: RPMI_8226, HL_60, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 75% identity similarity to TRPC7 there are:
4 structures (16 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

TRPC7 has been screened with 3 compounds (7 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)