Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRPC7 (Q9HCX4) - Overview - Molecular Target Synopsis

Protein


TRPC7, Short transient receptor potential channel 7
UniProt Q9HCX4

Also Known as TRPC7_HUMAN, TRPC7, TRP7

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRPC7 is active in the following subcellular-locations: cell membrane, nucleus envelope.
GO terms: TRPC7 is active in the following subcellular-locations: cation channel complex, cis-Golgi network, integral component of plasma membrane, nuclear envelope, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRPC7 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, HL_60, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to TRPC7 there are:
4 structures (16 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRPC7 has been screened with 3 compounds (7 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)