Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CSNK1G1 (Q9HCP0) - Overview - Molecular Target Synopsis

Protein


CSNK1G1, Casein kinase I isoform gamma-1
Enzyme Classification 2.7.11.1
UniProt Q9HCP0

Also Known as KC1G1_HUMAN, CSNK1G1

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. Monomer.

2CMW
STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITH 2-(2- HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
RCSB/PDB
Inspect Structure
See all 3D Structures for CSNK1G1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CSNK1G1 is active in the following subcellular-locations: cytoplasm.
GO terms: CSNK1G1 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CSNK1G1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, MCF7, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, KP4, NIH:OVCAR-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, HSMM

(see details)

RNA Interference


CSNK1G1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB453, SUM44. (see details)

3D Structures


For CSNK1G1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CSNK1G1 has been screened with 824 compounds (1513 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)