Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AGO4 (Q9HCK5) - Overview - Molecular Target Synopsis

Protein


AGO4, Protein argonaute-4
UniProt Q9HCK5

Also Known as AGO4_HUMAN, AGO4, EIF2C4, KIAA1567

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B (PubMed:19167051). Interacts with ZFP36 (PubMed:15766526).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
861ENSG00000134698ENST00000373210ENSP00000362306Q9HCK5-1

Sub-cellular localization


UniProt: AGO4 is active in the following subcellular-locations: cytoplasm, p-body.
GO terms: AGO4 is active in the following subcellular-locations: cytoplasm, cytosol, membrane, micro-ribonucleoprotein complex, nuclear body, nucleoplasm, P-body, RISC complex, RISC-loading complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AGO4 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, Hs 746T, OCI-AML2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, CD14-positive monocyte, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to AGO4 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis