Molecular Target Synopsis
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MSL2 (Q9HCI7) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4B86_C E3 ubiquitin-protein ligase MSL2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 67.8 18.4 No No
2 empty 2.15 64.1 17.5 No No
3 empty 2.19 64 14.8 No No
4 empty 1.56 65.1 16.3 No No
5 empty 2.36 61.7 12.8 No No
6 empty 2.56 66 16.5 No No
7 empty 2.44 71.3 8.8 No No
8 empty 2.39 67.4 6.7 No No
9 empty 1.48 67.7 5.6 No No
10 empty 2.63 59.1 8.4 No No
4B86_L E3 ubiquitin-protein ligase MSL2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 65.8 30.1 Yes No
2 empty 2.03 59.2 15.8 No No
3 empty 2.63 59.7 22.4 No No
4 empty 2.57 61.7 17.2 No No
5 empty 2.34 54.7 13.7 No No
6 empty 1.33 96.3 0 Yes No
7 empty 1.5 70.9 8.4 No No
8 empty 2.49 68 8.7 No No
9 empty 1.86 60.1 10.1 No No
10 empty 2.44 68.4 8.9 No No
4B7Y_C E3 ubiquitin-protein ligase MSL2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 66.1 16.2 No No
2 empty 2.17 62.6 15.8 No No
3 empty 2.46 62.2 23.6 No No
4 empty 1.32 66.2 12.7 No No
5 empty 1.56 97.4 0 Yes No
6 empty 2.31 68.5 12.9 No No
7 empty 1.98 62.3 10.8 No No
8 empty 2.28 62.7 8.2 No No
9 empty 2.33 64 6.2 No No
10 empty 1.99 50 5.8 No No
4B86_G E3 ubiquitin-protein ligase MSL2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 66.2 22 No No
2 empty 2.23 65.6 19.5 No No
3 empty 1.94 61.1 15.7 No No
4 empty 2.5 62.8 15.9 No No
5 empty 2.61 60.6 11.7 No No
6 empty 2.53 57.1 9.2 No No
7 empty 2.82 69.3 13.4 No No
8 empty 2.5 68.6 8.8 No No
9 empty 2.48 62.7 10.8 No No
10 empty 2.51 68.5 9.9 No No
4B86_D E3 ubiquitin-protein ligase MSL2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 67.2 16.7 No No
2 empty 2.15 61.4 22.8 No No
3 empty 2.38 65.6 17 No No
4 empty 2.43 69.9 11.3 No No
5 empty 2.57 74.5 7.9 No No
6 empty 2.32 66.5 8.6 No No
7 empty 2.74 58.6 7.1 No No
8 empty 1.47 70.2 7.6 No No
9 empty 2.63 73.5 7.4 No No
10 empty 1.68 69.2 6.5 No No
4B7Y_D E3 ubiquitin-protein ligase MSL2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 64.6 17 No No
2 empty 1.94 62.2 17.5 No No
3 empty 1.91 64.7 12.3 No No
4 empty 2.52 76.8 9.1 No No
5 empty 2.73 71.9 8 No No
6 empty 2.72 71.7 11.1 No No
7 empty 2.16 59.5 7.8 No No
8 empty 2.12 60.6 9 No No
9 empty 1.52 66.2 5.1 No No
10 empty 1.68 68.8 7.2 No No
4B86_K E3 ubiquitin-protein ligase MSL2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 64.6 15.4 No No
2 empty 2.16 61.7 12.8 No No
3 empty 2.1 63.5 7.9 No No
4 empty 2.65 63.3 17.6 No No
5 empty 2.58 63 11.7 No No
6 empty 2.37 67.8 9.9 No No
7 empty 2.58 75.2 7.7 No No
8 empty 2.77 65.8 8 No No
9 empty 2.52 75.2 8.9 No No
10 empty 1.4 70.8 5.6 No No
4B86_H E3 ubiquitin-protein ligase MSL2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 66.7 18.2 No No
2 empty 2.43 65.3 16.1 No No
3 empty 2.57 63.9 15.7 No No
4 empty 2.18 74.2 13.9 No No
5 empty 1.62 63.1 13.7 No No
6 empty 2.44 61 11.9 No No
7 empty 1.49 69.8 5.9 No No
8 empty 2.59 75.2 8.5 No No
9 empty 2.28 48.3 9.7 No No
10 empty 2.38 64.7 7.8 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MSL2 is involved in 13 interactions in the network.


Druggability
Overall Druggability Percentile: 55.68
Druggability for Cancer Therapeutics: 83.15
Druggability for Other Therapeutics: 38.43
Cancer-Associated
Cancer-associated percentile : 94.13
Network Articulation Point
Is MSL2 critical for communication in the network?


Detailed Graph Legend:Help