Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MSL2 (Q9HCI7) - Overview - Molecular Target Synopsis


MSL2, E3 ubiquitin-protein ligase MSL2
Enzyme Classification 2.3.2.-
UniProt Q9HCI7

Also Known as MSL2_HUMAN, MSL2, KIAA1585, MSL2L1, RNF184

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL1.

Inspect Structure
See all 3D Structures for MSL2

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: MSL2 is active in the following subcellular-locations: MSL complex, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MSL2 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: CCRF_CEM, MOLT_4, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, Jurkat, Clone E6-1, NIH:OVCAR-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HeLa-S3

(see details)

RNA Interference

MSL2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures

For MSL2 there are:
2 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis