Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SMURF1 (Q9HCE7) - Overview - Molecular Target Synopsis

Protein


SMURF1, E3 ubiquitin-protein ligase SMURF1
Enzyme Classification 2.3.2.26
UniProt Q9HCE7

Also Known as SMUF1_HUMAN, SMURF1, KIAA1625

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation. Interacts with MAVS; the interaction is mediated by NDFIP1 (PubMed:23087404).

2LTX
SMURF1 WW2 DOMAIN IN COMPLEX WITH A SMAD7 DERIVED PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for SMURF1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
757ENSG00000198742ENST00000361125ENSP00000354621Q9HCE7-1
731ENSG00000198742ENST00000361368ENSP00000355326Q9HCE7-2

Sub-cellular localization


UniProt: SMURF1 is active in the following subcellular-locations: cell membrane, cytoplasm.
GO terms: SMURF1 is active in the following subcellular-locations: axon, cytoplasm, cytosol, extracellular exosome, neuronal cell body, nucleoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SMURF1 has gain in 10 cell-lines, loss in 1 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, A498, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H322T, AsPC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

3D Structures


For SMURF1 there are:
5 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis