Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TMBIM4 (Q9HC24) - Overview - Molecular Target Synopsis

Protein


TMBIM4, Protein lifeguard 4
UniProt Q9HC24

Also Known as LFG4_HUMAN, TMBIM4, GAAP, LFG4

Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release. Interacts with ITPR3.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TMBIM4 is active in the following subcellular-locations: golgi apparatus membrane.
GO terms: TMBIM4 is active in the following subcellular-locations: Golgi membrane, Golgi stack, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TMBIM4 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, COLO205, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1143, ML-2, SK-BR-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HUVEC, MCF-7

(see details)