Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOF (Q9HBH0) - Overview - Molecular Target Synopsis

Protein


RHOF, Rho-related GTP-binding protein RhoF
UniProt Q9HBH0

Also Known as RHOF_HUMAN, RHOF, ARHF, RIF

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RHOF is active in the following subcellular-locations: cell membrane, cytoplasm, cytoskeleton.
GO terms: RHOF is active in the following subcellular-locations: cell cortex, cell division site, cytoplasm, cytoskeleton, cytosol, extracellular exosome, intracellular membrane-bounded organelle, plasma membrane, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOF has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, PC_3, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CAL-12T, COV413A, NCI-H2347

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, SK-N-SH

(see details)

3D Structures


At greater than 50% identity similarity to RHOF there are:
90 structures (157 chains) solved
75 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

RHOF is solved in complex with the approved drug(s):

FMN/RIBOFLAVIN 5'-PHOSPHATE (2WKP_A, 2WKQ_A, 2WKR_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOF has been screened with compounds ( bioactivities). (see details)