Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FOLH1B (Q9HBA9) - Overview - Molecular Target Synopsis

Protein


FOLH1B, Putative N-acetylated-alpha-linked acidic dipeptidase
Enzyme Classification 3.4.-.-
UniProt Q9HBA9

Also Known as FOH1B_HUMAN, FOLH1B, PSMAL

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity., Exhibits a dipeptidyl-peptidase IV type activity.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
442Q9HBA9-1

Sub-cellular localization


UniProt: FOLH1B is active in the following subcellular-locations: cytoplasm.
GO terms: FOLH1B is active in the following subcellular-locations: cytoplasm, extracellular exosome, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FOLH1B has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to FOLH1B there are:
75 structures (78 chains) solved
75 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

FOLH1B is solved in complex with the approved drug(s):

MET/METHIONINE (2CIJ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FOLH1B has been screened with compounds ( bioactivities). (see details)