Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CLK4 (Q9HAZ1) - Overview - Molecular Target Synopsis


CLK4, Dual specificity protein kinase CLK4
Enzyme Classification
UniProt Q9HAZ1

Also Known as CLK4_HUMAN, CLK4

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Interacts with UBL5.

X-RAY STRUCTURE OF CLK4-KD(146-480)/CX-4945 AT 2.46A
Inspect Structure
See all 3D Structures for CLK4

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: CLK4 is active in the following subcellular-locations: nucleus.
GO terms: CLK4 is active in the following subcellular-locations: nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CLK4 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MOLT_4, NCI_H226, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H596, NCI-H292, SIG-M5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, MCF-7, GM12878

(see details)

RNA Interference

CLK4 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H358, OAW42. (see details)

3D Structures

For CLK4 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CLK4 has been screened with 385 compounds (486 bioactivities), 97 compounds have bioactivities that show binding affinity of <= 500nM (130 bioactivities). (see details)