Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

FN3KRP (Q9HA64) - Overview - Molecular Target Synopsis


FN3KRP, Ketosamine-3-kinase
Enzyme Classification 2.7.1.-
UniProt Q9HA64

Also Known as KT3K_HUMAN, FN3KRP

Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: FN3KRP is active in the following subcellular-locations: cytosol.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project FN3KRP has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SNB_19, A549, SF_268

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G124, LN-229, SiHa

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HSMM

(see details)

RNA Interference

FN3KRP was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: TOV112D, MFE296. (see details)