Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAB39L (Q9H9S4) - Overview - Molecular Target Synopsis

Protein


CAB39L, Calcium-binding protein 39-like
UniProt Q9H9S4

Also Known as CB39L_HUMAN, CAB39L

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

3ZHP
HUMAN MST3 (STK24) IN COMPLEX WITH MO25BETA
RCSB/PDB
Inspect Structure
See all 3D Structures for CAB39L

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: CAB39L is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAB39L has gain in 1 cell-lines, loss in 10 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_15, SK_MEL_5, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC630, RCM-1, HT-55

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, NHLF, SK-N-SH

(see details)

3D Structures


For CAB39L there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis