Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MRPL44 (Q9H9J2) - Overview - Molecular Target Synopsis

Protein


MRPL44, 39S ribosomal protein L44, mitochondrial
Enzyme Classification 3.1.26.-
UniProt Q9H9J2

Also Known as RM44_HUMAN, MRPL44

Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

5OOL
STRUCTURE OF A NATIVE ASSEMBLY INTERMEDIATE OF THE HUMAN MITOCHONDRIAL RIBOSOME WITH UNFOLDED INTERFACIAL RRNA
RCSB/PDB
Inspect Structure
See all 3D Structures for MRPL44

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
332ENSG00000135900ENST00000258383ENSP00000258383Q9H9J2-1

Sub-cellular localization


UniProt: MRPL44 is active in the following subcellular-locations: mitochondrion.
GO terms: MRPL44 is active in the following subcellular-locations: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MRPL44 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, SK_MEL_5, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, C2BBe1, Daudi

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


For MRPL44 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis