Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AGO3 (Q9H9G7) - Overview - Molecular Target Synopsis

Protein


AGO3, Protein argonaute-3
Enzyme Classification 3.1.26.n2
UniProt Q9H9G7

Also Known as AGO3_HUMAN, AGO3, EIF2C3

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H. Interacts with EDC4.

5VM9
HUMAN ARGONAUTE3 BOUND TO GUIDE RNA
RCSB/PDB
Inspect Structure
See all 3D Structures for AGO3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
860ENSG00000126070ENST00000373191ENSP00000362287Q9H9G7-1
626ENSG00000126070ENST00000246314ENSP00000246314Q9H9G7-2

Sub-cellular localization


UniProt: AGO3 is active in the following subcellular-locations: cytoplasm, p-body.
GO terms: AGO3 is active in the following subcellular-locations: condensed nuclear chromosome, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, membrane, micro-ribonucleoprotein complex, nucleoplasm, P-body, RISC complex, RISC-loading complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AGO3 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H510A, OPM-2, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, A549

(see details)

3D Structures


For AGO3 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis