Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ANKZF1 (Q9H8Y5) - Overview - Molecular Target Synopsis

Protein


ANKZF1, Ankyrin repeat and zinc finger domain-containing protein 1
UniProt Q9H8Y5

Also Known as ANKZ1_HUMAN, ANKZF1, ZNF744

Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity). Interacts (via VIM motif) with VCP.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ANKZF1 is active in the following subcellular-locations: cytoplasm.
GO terms: ANKZF1 is active in the following subcellular-locations: Cdc48p-Npl4p-Vms1p AAA ATPase complex, cytoplasm, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ANKZF1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, SR, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, HCC364, KMS-26

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HMEC

(see details)