MOB1A (Q9H8S9) - Overview - Molecular Target Synopsis
MOB1A, MOB kinase activator 1A
Also Known as MOB1A_HUMAN, MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|216||ENSG00000114978||ENST00000396049||ENSP00000379364||Q9H8S9-1, Q3T1J9-1, Q921Y0-1, Q5RAE0-1|
GO terms: MOB1A is active in the following subcellular-locations: cytosol, extracellular exosome, nucleolus, nucleus.