Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTGES2 (Q9H7Z7) - Overview - Molecular Target Synopsis

Protein


PTGES2, Prostaglandin E synthase 2
Enzyme Classification 5.3.99.3
UniProt Q9H7Z7

Also Known as PGES2_HUMAN, PTGES2, C9orf15, PGES2

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PTGES2 is active in the following subcellular-locations: cytoplasm, golgi apparatus membrane, perinuclear region.
GO terms: PTGES2 is active in the following subcellular-locations: azurophil granule lumen, cytosol, extracellular region, Golgi membrane, integral component of membrane, mitochondrion, nucleus, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTGES2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCC_2998, SN12C, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EPLC-272H, BFTC-905, LS 174T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, K562

(see details)

3D Structures


At greater than 90% identity similarity to PTGES2 there are:
2 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

PTGES2 is solved in complex with the approved drug(s):

IMN/INDOMETHACIN (1Z9H_A, 1Z9H_B, 1Z9H_C, 1Z9H_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PTGES2 has been screened with 290 compounds (312 bioactivities), 96 compounds have bioactivities that show binding affinity of <= 500nM (96 bioactivities). (see details)